DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
GPRACVHPS
Uniprot ID:
Q86Y97
Source protein:
Histone-lysine N-methyltransferase KMT5C
Source gene:
KMT5C
Class:
DEG_SIAH_1
Location:
282:290
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9862
ASA_SCORE:
91.2111
COIL:
0.9107
CONS_SCORE:
0.397
DSS_SCORE:
0.3854
HELIX:
0.0403
FCONS_SCORE:
1.0706
RIG_SCORE:
0.6807
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D273N
SIDM00422
Hodgkin's Lymphoma
GDSC
GPRACVHPS
DEG_SIAH_1
0.0833
p.A299T
SIDM00216
Colorectal Carcinoma
GDSC
GPRACVHPS
DEG_SIAH_1
0.0833
Drug responses associated with KMT5C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GPRACVHPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86Y97
Histone-lysine N-methyltransferase KMT5C
DEG_SIAH_1
282:290
GPRACVHPS
SIAH1,SIAH2,SIAH3
0.9862
More...