ERO1B
UniProt ID: Q86YB8
Entrez ID: 56605
Protein name: ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members...
FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. {ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:21091435}.
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GO - Biological processes (BP):
protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]...
protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]
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GO - Molecular function (MF):
FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]; unfolded protein binding [GO:0051082]...
FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]; unfolded protein binding [GO:0051082]
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GO - Cellular component (CC):
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]...
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]
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ERO1B
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Kaplan plot for ERO1B in
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*NOTE: the Kaplan plots were collected from OncoLnc