DegronMD

Uniprot ID: Q86YB8

Source protein: ERO1-like protein beta

Source gene: ERO1B

Class: LIG_APCC_ABBA_1

Location: 353:358

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5206

ASA_SCORE: 56.1167

COIL: 0.7307

CONS_SCORE: 0.5494

DSS_SCORE: 0.2911

HELIX: 0.1792

FCONS_SCORE: 1.2535

RIG_SCORE: 0.7822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E359Q	SIDM01186	Breast Carcinoma	GDSC	FPMHFD	LIG_APCC_ABBA_1	0.3056
p.E359Q	UACC-893	breast	COSMIC	FPMHFD	LIG_APCC_ABBA_1	0.3056
p.G365A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	FPMHFD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YB8	ERO1-like protein beta	LIG_APCC_ABBA_1	353:358	FPMHFD	APC,CDC20,FZR1	0.5206	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons