FUNCTION: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated ...
FUNCTION: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260). {ECO:0000250|UniProtKB:Q8BMT4, ECO:0000269|PubMed:23545260}.
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GO - Biological processes (BP):
immune response [GO:0006955]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; superoxide metabolic process [GO:0006801]; transforming growth factor beta1 activation [GO:0036364]; transforming growth factor beta rec...
immune response [GO:0006955]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; superoxide metabolic process [GO:0006801]; transforming growth factor beta1 activation [GO:0036364]; transforming growth factor beta receptor signaling pathway [GO:0007179]
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GO - Molecular function (MF):
transforming growth factor beta binding [GO:0050431]...
transforming growth factor beta binding [GO:0050431]
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GO - Cellular component (CC):
cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]...
cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
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