DegronMD

Uniprot ID: Q86YC3

Source protein: Transforming growth factor beta activator LRRC33

Source gene: NRROS

Class: DEG_ODPH_VHL_1

Location: 393:406

E3 ligase: VHL

DEGRON score: 0.763

ASA_SCORE: 48.9786

COIL: 0.7535

CONS_SCORE: 0.4402

DSS_SCORE: 0.0654

HELIX: 0.1159

FCONS_SCORE: 0.7483

RIG_SCORE: 0.7903

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P395A	TCGA-34-2596	LUSC	TCGA	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7503
p.P395A	DO26508	LUSC	ICGC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7503
p.P395A	SIDM00710	Small Cell Lung Carcinoma	GDSC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7503
p.P395A	NCI-H2081	lung	COSMIC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7503
p.R405H	TCGA-EO-A3KX	UCEC	TCGA	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7133
p.R405H	DO219774	UCEC	ICGC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7133
p.G396E	TCGA-UF-A7JF	HNSC	TCGA	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.6087
p.G396E	DO52116	HNSC	ICGC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.6087
p.L397R	DO220901	MELA	ICGC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7316
p.P395L	SIDM00710	Small Cell Lung Carcinoma	GDSC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7582
p.P395L	NCI-H2081	lung	COSMIC	LAPGLASCLGSLRL	DEG_ODPH_VHL_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YC3	Transforming growth factor beta activator LRRC33	DEG_ODPH_VHL_1	393:406	LAPGLASCLGSLRL	VHL	0.763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons