DegronMD - Q86YF9(DZIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S673P	TCGA-AA-A010	COAD	TCGA	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.2778
p.T676M	TCGA-DU-6392	LGG	TCGA	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.6312
p.E685K	TCGA-JW-A5VL	CESC	TCGA	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.2222
p.P669S	TCGA-WE-AAA0	SKCM	TCGA	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1667
p.P669S	SIDM01059	Melanoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1667
p.P669S	ACH-000915	Skin Cancer	CCLE	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1667
p.P669S	IPC-298	skin	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1667
p.P679L	TCGA-YD-A9TA	SKCM	TCGA	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.6471
p.P681R	DO219014	BLCA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.7512
p.E666K	DO49976	CESC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.0833
p.P681L	DO44087	COAD	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.7582
p.R674Q	DO233139	GACA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.3056
p.N689K	DO228952	LICA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1111
p.D669E	DO228986	LICA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1667
p.P687Q	DO32916	PACA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1667
p.P679S	DO37406	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.5641
p.P679S	DO48665	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.5641
p.P683S	DO37471	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.2778
p.P683S	DO51270	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.2778
p.A677T	DO222392	STAD	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.7139
p.P685L	DO223286	UCEC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.2222
p.P683T	DO41572	UCEC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.2778
p.L682R	DO43971	UCEC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.3056
p.T677A	SIDM00014	Colorectal Carcinoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.7139
p.T677A	LIM1215	large intestine	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.7139
p.D689N	SIDM00118	Colorectal Carcinoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1111
p.D689N	ACH-001081	Colon/Colorectal Cancer	CCLE	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1111
p.D689N	HCC2998	large intestine	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1111
p.T677N	SIDM01551	Gastric Carcinoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.7055
p.T677N	ACH-000485	Gastric Cancer	CCLE	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation altering degron motif	0.7055
p.D670N	HCC2998	large intestine	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	675:681	Mutation rewiring degron network	0.1944

Kaplan plot for DZIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DZIP1

UniProt ID: Q86YF9

Entrez ID: 22873

Protein name: Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DZIP1 in