DegronMD

Uniprot ID: Q86YF9

Source protein: Cilium assembly protein DZIP1

Source gene: DZIP1

Class: DEG_SCF_FBW7_1

Location: 675:681

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 84.7857

COIL: 0.9623

CONS_SCORE: 0.3698

DSS_SCORE: 0.7526

HELIX: 0.0081

FCONS_SCORE: 1.292

RIG_SCORE: 0.6397

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S673P	TCGA-AA-A010	COAD	TCGA	ITTPPFS	DEG_SCF_FBW7_1	0.2778
p.T676M	TCGA-DU-6392	LGG	TCGA	ITTPPFS	DEG_SCF_FBW7_1	0.6312
p.E685K	TCGA-JW-A5VL	CESC	TCGA	ITTPPFS	DEG_SCF_FBW7_1	0.2222
p.P669S	TCGA-WE-AAA0	SKCM	TCGA	ITTPPFS	DEG_SCF_FBW7_1	0.1667
p.P669S	SIDM01059	Melanoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	0.1667
p.P669S	ACH-000915	Skin Cancer	CCLE	ITTPPFS	DEG_SCF_FBW7_1	0.1667
p.P669S	IPC-298	skin	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	0.1667
p.P679L	TCGA-YD-A9TA	SKCM	TCGA	ITTPPFS	DEG_SCF_FBW7_1	0.6471
p.P681R	DO219014	BLCA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.7512
p.E666K	DO49976	CESC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.0833
p.P681L	DO44087	COAD	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.7582
p.R674Q	DO233139	GACA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.3056
p.N689K	DO228952	LICA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.1111
p.D669E	DO228986	LICA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.1667
p.P687Q	DO32916	PACA	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.1667
p.P679S	DO37406	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.5641
p.P679S	DO48665	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.5641
p.P683S	DO37471	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.2778
p.P683S	DO51270	SKCM	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.2778
p.A677T	DO222392	STAD	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.7139
p.P685L	DO223286	UCEC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.2222
p.P683T	DO41572	UCEC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.2778
p.L682R	DO43971	UCEC	ICGC	ITTPPFS	DEG_SCF_FBW7_1	0.3056
p.T677A	SIDM00014	Colorectal Carcinoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	0.7139
p.T677A	LIM1215	large_intestine	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	0.7139
p.D689N	SIDM00118	Colorectal Carcinoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	0.1111
p.D689N	ACH-001081	Colon/Colorectal Cancer	CCLE	ITTPPFS	DEG_SCF_FBW7_1	0.1111
p.D689N	HCC2998	large_intestine	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	0.1111
p.T677N	SIDM01551	Gastric Carcinoma	GDSC	ITTPPFS	DEG_SCF_FBW7_1	0.7055
p.T677N	ACH-000485	Gastric Cancer	CCLE	ITTPPFS	DEG_SCF_FBW7_1	0.7055
p.D670N	HCC2998	large_intestine	COSMIC	ITTPPFS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITTPPFS

Degron related mutations and impact score

Drug responses associated with DZIP1 mutations

All proteins holding degron of ITTPPFS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YF9	Cilium assembly protein DZIP1	DEG_SCF_FBW7_1	675:681	ITTPPFS	FBXW7	0.9902	More...