DegronMD - Q86YL7(PDPN)

FUNCTION: Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed:25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). Does not have any effect on folic acid or amino acid transport (By similarity). {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15231832, ECO:0000269|PubMed:15515019, ECO:0000269|PubMed:17046996, ECO:0000269|PubMed:17222411, ECO:0000269|PubMed:17616532, ECO:0000269|PubMed:18215137, ECO:0000269|PubMed:18541721, ECO:0000269|PubMed:19268462, ECO:0000269|PubMed:20962267, ECO:0000269|PubMed:21376833, ECO:0000269|PubMed:25486435, ECO:0000269|PubMed:9651190}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F57L	TCGA-55-7994	LUAD	TCGA	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.F57L	DO45311	LUAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.S44Y	TCGA-CQ-7071	HNSC	TCGA	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1667
p.S44Y	DO49069	HNSC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1667
p.P40L	TCGA-D3-A51J	SKCM	TCGA	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.0556
p.P40L	DO47359	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.0556
p.W50S	TCGA-SP-A6QD	PCPG	TCGA	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.7874
p.F57S	DO223357	CLLE	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.A50V	DO233079	GACA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6936
p.A50V	DO19593	KIRC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6936
p.A50V	DO222351	STAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6936
p.L55S	DO233693	GACA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.7667
p.G66V	DO229024	LICA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.0556
p.S54I	DO229032	LICA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.7341
p.T47R	DO24970	LUAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.25
p.S46T	DO26240	LUAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.2222
p.S56N	DO222875	MELA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.7069
p.A63S	DO50671	ORCA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1389
p.A59S	DO232036	ORCA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.25
p.E45Q	DO29790	OV	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1944
p.H49Q	DO33184	PACA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.A57T	DO51104	PRAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.T43A	DO229456	SKCA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1389
p.E45D	DO37603	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1944
p.H49Y	DO47646	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.A63V	DO47646	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1389
p.A63V	DO42033	UCEC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1389
p.S46N	DO51294	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.2222
p.P55S	DO47769	STAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6752
p.P55S	DO41235	UCEC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6752
p.V48I	DO41823	UCEC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.2778
p.I62M	SIDM00346	Chronic Myelogenous Leukemia	GDSC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1667
p.I62M	ACH-000301	Leukemia	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1667
p.I62M	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1667
p.G49V	ACH-000627	Lung Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.G49V	LCLC-103H	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.E42K	ACH-000746	Gastric Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1111
p.E42K	ACH-000825	Lung Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1111
p.E42K	HOP-92	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1111
p.L59F	ACH-000829	Myeloma	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.25
p.E52Q	ACH-001131	Skin Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6744
p.E52Q	ACH-001958	lung	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6744
p.E52Q	MS-1	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6744
p.T47I	ACH-001608	Brain Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.25
p.E52K	ACH-002159	Skin Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.7022
p.E52K	M14	skin	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.7022
p.V62M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.1667
p.A59T	SNU-1040	large intestine	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.25
p.E57K	M14	skin	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.E47K	HOP-92	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.25
p.E57Q	MS-1	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation rewiring degron network	0.3056
p.G54V	LCLC-103H	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	50:56	Mutation altering degron motif	0.6421

Kaplan plot for PDPN in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDPN

UniProt ID: Q86YL7

Entrez ID: 10630

Protein name: Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PDPN in