DegronMD

Uniprot ID: Q86YL7

Source protein: Podoplanin

Source gene: PDPN

Class: DEG_SCF_FBW7_1

Location: 50:56

E3 ligase: FBXW7

DEGRON score: 0.9243

ASA_SCORE: 55.2286

COIL: 0.6563

CONS_SCORE: 0.6363

DSS_SCORE: 0.6276

HELIX: 0.0449

FCONS_SCORE: 1.1016

RIG_SCORE: 0.7267

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F57L	TCGA-55-7994	LUAD	TCGA	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.F57L	DO45311	LUAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.S44Y	TCGA-CQ-7071	HNSC	TCGA	VVTPGTS	DEG_SCF_FBW7_1	0.1667
p.S44Y	DO49069	HNSC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.1667
p.P40L	TCGA-D3-A51J	SKCM	TCGA	VVTPGTS	DEG_SCF_FBW7_1	0.0556
p.P40L	DO47359	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.0556
p.W50S	TCGA-SP-A6QD	PCPG	TCGA	VVTPGTS	DEG_SCF_FBW7_1	0.7874
p.F57S	DO223357	CLLE	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.A50V	DO233079	GACA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.6936
p.A50V	DO19593	KIRC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.6936
p.A50V	DO222351	STAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.6936
p.L55S	DO233693	GACA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.7667
p.G66V	DO229024	LICA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.0556
p.S54I	DO229032	LICA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.7341
p.T47R	DO24970	LUAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.25
p.S46T	DO26240	LUAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.2222
p.S56N	DO222875	MELA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.7069
p.A63S	DO50671	ORCA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.1389
p.A59S	DO232036	ORCA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.25
p.E45Q	DO29790	OV	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.1944
p.H49Q	DO33184	PACA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.A57T	DO51104	PRAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.T43A	DO229456	SKCA	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.1389
p.E45D	DO37603	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.1944
p.H49Y	DO47646	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.A63V	DO47646	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.1389
p.A63V	DO42033	UCEC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.1389
p.S46N	DO51294	SKCM	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.2222
p.P55S	DO47769	STAD	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.6752
p.P55S	DO41235	UCEC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.6752
p.V48I	DO41823	UCEC	ICGC	VVTPGTS	DEG_SCF_FBW7_1	0.2778
p.I62M	SIDM00346	Chronic Myelogenous Leukemia	GDSC	VVTPGTS	DEG_SCF_FBW7_1	0.1667
p.I62M	ACH-000301	Leukemia	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.1667
p.I62M	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.1667
p.G49V	ACH-000627	Lung Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.G49V	LCLC-103H	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.E42K	ACH-000746	Gastric Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.1111
p.E42K	ACH-000825	Lung Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.1111
p.E42K	HOP-92	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.1111
p.L59F	ACH-000829	Myeloma	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.25
p.E52Q	ACH-001131	Skin Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.6744
p.E52Q	ACH-001958	lung	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.6744
p.E52Q	MS-1	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.6744
p.T47I	ACH-001608	Brain Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.25
p.E52K	ACH-002159	Skin Cancer	CCLE	VVTPGTS	DEG_SCF_FBW7_1	0.7022
p.E52K	M14	skin	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.7022
p.V62M	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.1667
p.A59T	SNU-1040	large_intestine	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.25
p.E57K	M14	skin	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.E47K	HOP-92	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.25
p.E57Q	MS-1	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.3056
p.G54V	LCLC-103H	lung	COSMIC	VVTPGTS	DEG_SCF_FBW7_1	0.6421

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTPGTS

Degron related mutations and impact score

Drug responses associated with PDPN mutations

All proteins holding degron of VVTPGTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YL7	Podoplanin	DEG_SCF_FBW7_1	50:56	VVTPGTS	FBXW7	0.9243	More...