DegronMD - Q86YM7(HOMER1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L136I	TCGA-3M-AB47	STAD	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1667
p.L136I	DO222327	STAD	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1667
p.P127A	TCGA-BH-A0H7	BRCA	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.7503
p.P127A	DO1984	BRCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.7503
p.D135Y	TCGA-DD-A73E	LIHC	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1944
p.D135Y	DO48483	LIHC	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1944
p.K120N	TCGA-DK-AA75	BLCA	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation substituting flanking lysine	0.3611
p.K120N	DO219012	BLCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation substituting flanking lysine	0.3611
p.G134R	TCGA-E6-A1LX	UCEC	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.2222
p.G134R	DO41020	UCEC	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.2222
p.E130K	TCGA-EB-A5UL	SKCM	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.7022
p.E130K	DO47601	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.7022
p.S117L	TCGA-EK-A2R7	CESC	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1667
p.S117L	TCGA-UY-A9PB	BLCA	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1667
p.S117L	DO219041	BLCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1667
p.S117L	DO49943	CESC	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1667
p.P127H	TCGA-G4-6309	COAD	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.7694
p.P127H	DO7810	COAD	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.7694
p.A132T	TCGA-ND-A4WC	UCS	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.2778
p.Q136K	DO228974	LICA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1667
p.T114N	DO228974	LICA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation substituting flanking lysine	0.1944
p.P127T	DO228971	LICA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.7031
p.L123R	DO50857	LIRI	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.8428
p.R137C	DO228142	PBCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.1389
p.R123W	DO37406	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.8634
p.R123W	DO47407	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.8634
p.R123W	HT-115	large intestine	COSMIC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation altering degron motif	0.8634
p.E119K	DO37483	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	123:130	Mutation rewiring degron network	0.2222

Kaplan plot for HOMER1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOMER1

UniProt ID: Q86YM7

Entrez ID: 9456

Protein name: Homer protein homolog 1 (Homer-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOMER1 in