DegronMD

Uniprot ID: Q86YM7

Source protein: Homer protein homolog 1

Source gene: HOMER1

Class: DEG_SCF_FBW7_2

Location: 123:130

E3 ligase: FBXW7

DEGRON score: 0.9546

ASA_SCORE: 82.175

COIL: 0.7315

CONS_SCORE: 0.52

DSS_SCORE: 0.7606

HELIX: 0.1803

FCONS_SCORE: 1.1696

RIG_SCORE: 0.6179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L136I	TCGA-3M-AB47	STAD	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.1667
p.L136I	DO222327	STAD	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.1667
p.P127A	TCGA-BH-A0H7	BRCA	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.7503
p.P127A	DO1984	BRCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.7503
p.D135Y	TCGA-DD-A73E	LIHC	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.1944
p.D135Y	DO48483	LIHC	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.1944
p.K120N	TCGA-DK-AA75	BLCA	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.3611
p.K120N	DO219012	BLCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.3611
p.G134R	TCGA-E6-A1LX	UCEC	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.2222
p.G134R	DO41020	UCEC	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.2222
p.E130K	TCGA-EB-A5UL	SKCM	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.7022
p.E130K	DO47601	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.7022
p.S117L	TCGA-EK-A2R7	CESC	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.1667
p.S117L	TCGA-UY-A9PB	BLCA	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.1667
p.S117L	DO219041	BLCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.1667
p.S117L	DO49943	CESC	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.1667
p.P127H	TCGA-G4-6309	COAD	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.7694
p.P127H	DO7810	COAD	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.7694
p.A132T	TCGA-ND-A4WC	UCS	TCGA	LTSTPSQE	DEG_SCF_FBW7_2	0.2778
p.Q136K	DO228974	LICA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.1667
p.T114N	DO228974	LICA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.1944
p.P127T	DO228971	LICA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.7031
p.L123R	DO50857	LIRI	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.8428
p.R137C	DO228142	PBCA	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.1389
p.R123W	DO37406	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.8634
p.R123W	DO47407	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.8634
p.R123W	HT-115	large_intestine	COSMIC	LTSTPSQE	DEG_SCF_FBW7_2	0.8634
p.E119K	DO37483	SKCM	ICGC	LTSTPSQE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YM7	Homer protein homolog 1	DEG_SCF_FBW7_2	123:130	LTSTPSQE	FBXW7	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTSTPSQE

Degron related mutations and impact score

Drug responses associated with HOMER1 mutations

All proteins holding degron of LTSTPSQE