DegronMD - Q86YP4(GATAD2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S262T	TCGA-50-5049	LUAD	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation blocking phosphorylation signal	0.5556
p.S262T	DO23705	LUAD	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation blocking phosphorylation signal	0.5556
p.T263I	TCGA-55-8302	LUAD	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation blocking phosphorylation signal	0.5833
p.A271P	TCGA-AJ-A3OJ	UCEC	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation altering degron motif	0.7503
p.A271P	DO42753	UCEC	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation altering degron motif	0.7503
p.A271P	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation altering degron motif	0.7503
p.A271P	ACH-000995	Leukemia	CCLE	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation altering degron motif	0.7503
p.A271P	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation altering degron motif	0.7503
p.P265L	TCGA-BS-A0UL	UCEC	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1944
p.P265L	DO41319	UCEC	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1944
p.G283E	TCGA-VQ-A8PX	STAD	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.2778
p.G283E	DO51778	STAD	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.2778
p.G264W	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1667
p.G264W	ACH-000781	Lung Cancer	CCLE	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1667
p.G264W	NCI-H2023	lung	COSMIC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1667
p.I286V	SIDM01045	Endometrial Carcinoma	GDSC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1944
p.I286V	ACH-000978	Endometrial/Uterine Cancer	CCLE	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1944
p.I286V	EN	endometrium	COSMIC	LAPRASVPSVQI	DEG_ODPH_VHL_1	270:281	Mutation rewiring degron network	0.1944

Kaplan plot for GATAD2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GATAD2A

UniProt ID: Q86YP4

Entrez ID: 54815

Protein name: Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GATAD2A in