DegronMD

Uniprot ID: Q86YP4

Source protein: Transcriptional repressor p66-alpha

Source gene: GATAD2A

Class: DEG_ODPH_VHL_1

Location: 270:281

E3 ligase: VHL

DEGRON score: 0.9085

ASA_SCORE: 93.8833

COIL: 0.8811

CONS_SCORE: 0.3642

DSS_SCORE: 0.3908

HELIX: 0.0875

FCONS_SCORE: 0.936

RIG_SCORE: 0.7366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S262T	TCGA-50-5049	LUAD	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.5556
p.S262T	DO23705	LUAD	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.5556
p.T263I	TCGA-55-8302	LUAD	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.5833
p.A271P	TCGA-AJ-A3OJ	UCEC	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.7503
p.A271P	DO42753	UCEC	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.7503
p.A271P	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.7503
p.A271P	ACH-000995	Leukemia	CCLE	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.7503
p.A271P	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.7503
p.P265L	TCGA-BS-A0UL	UCEC	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1944
p.P265L	DO41319	UCEC	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1944
p.G283E	TCGA-VQ-A8PX	STAD	TCGA	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.2778
p.G283E	DO51778	STAD	ICGC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.2778
p.G264W	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1667
p.G264W	ACH-000781	Lung Cancer	CCLE	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1667
p.G264W	NCI-H2023	lung	COSMIC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1667
p.I286V	SIDM01045	Endometrial Carcinoma	GDSC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1944
p.I286V	ACH-000978	Endometrial/Uterine Cancer	CCLE	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1944
p.I286V	EN	endometrium	COSMIC	LAPRASVPSVQI	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YP4	Transcriptional repressor p66-alpha	DEG_ODPH_VHL_1	270:281	LAPRASVPSVQI	VHL	0.9085	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons