DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
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POTED
UniProt ID:
Q86YR6
Entrez ID:
100288966
Protein name:
POTE ankyrin domain family member D (ANKRD26-like family B member 3) (Ankyrin repeat domain-containing protein 21) (Prostate, ovary, testis-expressed protein) (Protein POTE)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
plasma membrane [GO:0005886]...
plasma membrane [GO:0005886]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
POTED
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.N204S
DO229268
THCA
ICGC
RRCQLNVLD
DEG_APCC_DBOX_1
195:203
Mutation rewiring degron network
0.3056
p.N204K
DO229242
THCA
ICGC
RRCQLNVLD
DEG_APCC_DBOX_1
195:203
Mutation rewiring degron network
0.3056
p.A209V
RPMI-8866
haematopoietic and lymphoid tissue
COSMIC
RRCQLNVLD
DEG_APCC_DBOX_1
195:203
Mutation rewiring degron network
0.1667
p.V189A
SNG-M
endometrium
COSMIC
RRCQLNVLD
DEG_APCC_DBOX_1
195:203
Mutation rewiring degron network
0.1667
p.A209P
RPMI-8866
haematopoietic and lymphoid tissue
COSMIC
RRCQLNVLD
DEG_APCC_DBOX_1
195:203
Mutation rewiring degron network
0.1667
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for POTED in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc