DegronMD

Uniprot ID: Q86YR6

Source protein: POTE ankyrin domain family member D

Source gene: POTED

Class: DEG_APCC_DBOX_1

Location: 195:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5236

ASA_SCORE: 65.6111

COIL: 0.7224

CONS_SCORE: 0.5528

DSS_SCORE: 0.0679

HELIX: 0.0563

FCONS_SCORE: 0.8525

RIG_SCORE: 0.8784

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N204S	DO229268	THCA	ICGC	RRCQLNVLD	DEG_APCC_DBOX_1	0.3056
p.N204K	DO229242	THCA	ICGC	RRCQLNVLD	DEG_APCC_DBOX_1	0.3056
p.A209V	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	RRCQLNVLD	DEG_APCC_DBOX_1	0.1667
p.V189A	SNG-M	endometrium	COSMIC	RRCQLNVLD	DEG_APCC_DBOX_1	0.1667
p.A209P	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	RRCQLNVLD	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YR6	POTE ankyrin domain family member D	DEG_APCC_DBOX_1	195:203	RRCQLNVLD	APC,CDC20,FZR1	0.5236	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons