DegronMD - Q86YV9(HPS6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P768L	TCGA-06-0124	GBM	TCGA	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation altering degron motif	0.6471
p.P768L	DO12214	GBM	ICGC	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation altering degron motif	0.6471
p.L754I	TCGA-AG-A002	READ	TCGA	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation rewiring degron network	0.0556
p.D763Y	TCGA-BP-5168	KIRC	TCGA	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation rewiring degron network	0.3056
p.D763Y	DO18671	KIRC	ICGC	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation rewiring degron network	0.3056
p.P769S	TCGA-EE-A2GR	SKCM	TCGA	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation altering degron motif	0.5641
p.P769S	DO37996	SKCM	ICGC	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation altering degron motif	0.5641
p.P764S	TCGA-EO-A22X	UCEC	TCGA	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation altering degron motif	0.6752
p.P764S	DO43907	UCEC	ICGC	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation altering degron motif	0.6752
p.D763N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation rewiring degron network	0.3056
p.D763N	ACH-000995	Leukemia	CCLE	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation rewiring degron network	0.3056
p.D763N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSTPPPT	DEG_SCF_FBW7_1	764:770	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons