DegronMD

Uniprot ID: Q86YV9

Source protein: Hermansky-Pudlak syndrome 6 protein

Source gene: HPS6

Class: DEG_SCF_FBW7_1

Location: 764:770

E3 ligase: FBXW7

DEGRON score: 0.8897

ASA_SCORE: 71.2857

COIL: 0.9703

CONS_SCORE: 0.7416

DSS_SCORE: 0.7227

HELIX: 0.014

FCONS_SCORE: 1.351

RIG_SCORE: 0.6127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P768L	TCGA-06-0124	GBM	TCGA	PSTPPPT	DEG_SCF_FBW7_1	0.6471
p.P768L	DO12214	GBM	ICGC	PSTPPPT	DEG_SCF_FBW7_1	0.6471
p.L754I	TCGA-AG-A002	READ	TCGA	PSTPPPT	DEG_SCF_FBW7_1	0.0556
p.D763Y	TCGA-BP-5168	KIRC	TCGA	PSTPPPT	DEG_SCF_FBW7_1	0.3056
p.D763Y	DO18671	KIRC	ICGC	PSTPPPT	DEG_SCF_FBW7_1	0.3056
p.P769S	TCGA-EE-A2GR	SKCM	TCGA	PSTPPPT	DEG_SCF_FBW7_1	0.5641
p.P769S	DO37996	SKCM	ICGC	PSTPPPT	DEG_SCF_FBW7_1	0.5641
p.P764S	TCGA-EO-A22X	UCEC	TCGA	PSTPPPT	DEG_SCF_FBW7_1	0.6752
p.P764S	DO43907	UCEC	ICGC	PSTPPPT	DEG_SCF_FBW7_1	0.6752
p.D763N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTPPPT	DEG_SCF_FBW7_1	0.3056
p.D763N	ACH-000995	Leukemia	CCLE	PSTPPPT	DEG_SCF_FBW7_1	0.3056
p.D763N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPPPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV9	Hermansky-Pudlak syndrome 6 protein	DEG_SCF_FBW7_1	764:770	PSTPPPT	FBXW7	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons