DegronMD - Q8IU57(IFNLR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q355H	TCGA-44-7670	LUAD	TCGA	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0556
p.V338I	TCGA-AY-A54L	COAD	TCGA	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2778
p.V338I	SIDM00217	Colorectal Carcinoma	GDSC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2778
p.V338I	SNU-1040	large intestine	COSMIC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2778
p.G337D	TCGA-DU-6407	LGG	TCGA	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.25
p.Q341H	TCGA-KL-8324	KICH	TCGA	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation altering degron motif	0.647
p.Q341H	DO220332	KICH	ICGC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation altering degron motif	0.647
p.E349K	DO15206	HNSC	ICGC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.E349K	DO28346	OV	ICGC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.E349K	DO42512	UCEC	ICGC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.S331L	DO48009	STAD	ICGC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0833
p.H354R	SIDM01095	Rhabdomyosarcoma	GDSC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0833
p.H354R	ACH-000833	Sarcoma	CCLE	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0833
p.H354R	SJRH30	soft tissue	COSMIC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0833
p.D330N	SIDM00694	Other Solid Cancers	GDSC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0556
p.D330Y	SIDM00937	Oral Cavity Carcinoma	GDSC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0556
p.D330Y	ACH-000832	Head and Neck Cancer	CCLE	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0556
p.D330Y	CAL-27	upper aerodigestive tract	COSMIC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0556
p.P347S	NCI-H1770	lung	COSMIC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2778
p.P344H	MFE-319	endometrium	COSMIC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation altering degron motif	0.7694
p.D355N	MRK-nu-1	breast	COSMIC	FQPYIE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.0556

Kaplan plot for IFNLR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFNLR1

UniProt ID: Q8IU57

Entrez ID: 163702

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IFNLR1 in