DegronMD

Uniprot ID: Q8IU57

Source protein: Interferon lambda receptor 1

Source gene: IFNLR1

Class: LIG_APCC_ABBA_1

Location: 340:345

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9547

ASA_SCORE: 97.7333

COIL: 0.8232

CONS_SCORE: 0.4705

DSS_SCORE: 0.7894

HELIX: 0.034

FCONS_SCORE: 1.4044

RIG_SCORE: 0.7195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q355H	TCGA-44-7670	LUAD	TCGA	FQPYIE	LIG_APCC_ABBA_1	0.0556
p.V338I	TCGA-AY-A54L	COAD	TCGA	FQPYIE	LIG_APCC_ABBA_1	0.2778
p.V338I	SIDM00217	Colorectal Carcinoma	GDSC	FQPYIE	LIG_APCC_ABBA_1	0.2778
p.V338I	SNU-1040	large_intestine	COSMIC	FQPYIE	LIG_APCC_ABBA_1	0.2778
p.G337D	TCGA-DU-6407	LGG	TCGA	FQPYIE	LIG_APCC_ABBA_1	0.25
p.Q341H	TCGA-KL-8324	KICH	TCGA	FQPYIE	LIG_APCC_ABBA_1	0.647
p.Q341H	DO220332	KICH	ICGC	FQPYIE	LIG_APCC_ABBA_1	0.647
p.E349K	DO15206	HNSC	ICGC	FQPYIE	LIG_APCC_ABBA_1	0.2222
p.E349K	DO28346	OV	ICGC	FQPYIE	LIG_APCC_ABBA_1	0.2222
p.E349K	DO42512	UCEC	ICGC	FQPYIE	LIG_APCC_ABBA_1	0.2222
p.S331L	DO48009	STAD	ICGC	FQPYIE	LIG_APCC_ABBA_1	0.0833
p.H354R	SIDM01095	Rhabdomyosarcoma	GDSC	FQPYIE	LIG_APCC_ABBA_1	0.0833
p.H354R	ACH-000833	Sarcoma	CCLE	FQPYIE	LIG_APCC_ABBA_1	0.0833
p.H354R	SJRH30	soft_tissue	COSMIC	FQPYIE	LIG_APCC_ABBA_1	0.0833
p.D330N	SIDM00694	Other Solid Cancers	GDSC	FQPYIE	LIG_APCC_ABBA_1	0.0556
p.D330Y	SIDM00937	Oral Cavity Carcinoma	GDSC	FQPYIE	LIG_APCC_ABBA_1	0.0556
p.D330Y	ACH-000832	Head and Neck Cancer	CCLE	FQPYIE	LIG_APCC_ABBA_1	0.0556
p.D330Y	CAL-27	upper_aerodigestive_tract	COSMIC	FQPYIE	LIG_APCC_ABBA_1	0.0556
p.P347S	NCI-H1770	lung	COSMIC	FQPYIE	LIG_APCC_ABBA_1	0.2778
p.P344H	MFE-319	endometrium	COSMIC	FQPYIE	LIG_APCC_ABBA_1	0.7694
p.D355N	MRK-nu-1	breast	COSMIC	FQPYIE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IU57	Interferon lambda receptor 1	LIG_APCC_ABBA_1	340:345	FQPYIE	APC,CDC20,FZR1	0.9547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons