DegronMD - Q8IU99(CALHM1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A283V	TCGA-AX-A2HD	UCEC	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.25
p.A283V	TCGA-CG-5728	STAD	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.25
p.A283V	DO38619	STAD	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.25
p.A283V	DO42608	UCEC	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.25
p.R287M	TCGA-DZ-6133	KIRP	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.8632
p.R287M	DO20762	KIRP	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.8632
p.R287K	TCGA-FW-A3R5	SKCM	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7237
p.R287K	DO37406	SKCM	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7237
p.R287K	SIDM01617	Endometrial Carcinoma	GDSC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7237
p.R287K	ACH-000994	Endometrial/Uterine Cancer	CCLE	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7237
p.T304M	TCGA-HE-7130	KIRP	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.T304M	DO20776	KIRP	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.R291H	TCGA-KN-8428	KICH	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7133
p.R291H	DO227709	COCA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7133
p.R291H	DO220484	KICH	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7133
p.P280S	TCGA-NC-A5HM	LUSC	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1667
p.P280S	DO219195	LUSC	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1667
p.T298I	TCGA-QC-A7B5	SARC	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2222
p.T298I	DO232224	PBCA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2222
p.T298I	DO220239	SARC	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2222
p.T279N	DO229009	LICA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1389
p.E285K	DO220877	MELA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.3056
p.P280T	DO46438	OV	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1667
p.N300S	DO232224	PBCA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1667
p.R291C	SIDM00217	Colorectal Carcinoma	GDSC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.719
p.R291C	SNU-1040	large intestine	COSMIC	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.719
p.T278M	ACH-000419	Myeloma	CCLE	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1111
p.T278M	ACH-001541	Myeloma	CCLE	EREKLRGIT	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1111

Kaplan plot for CALHM1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CALHM1

UniProt ID: Q8IU99

Entrez ID: 255022

Protein name: Calcium homeostasis modulator protein 1 (Protein FAM26C)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CALHM1 in