DegronMD

Uniprot ID: Q8IU99

Source protein: Calcium homeostasis modulator protein 1

Source gene: CALHM1

Class: DEG_APCC_DBOX_1

Location: 286:294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 87.7556

COIL: 0.5327

CONS_SCORE: 0.4817

DSS_SCORE: 0.7114

HELIX: 0.4466

FCONS_SCORE: 1.2627

RIG_SCORE: 0.7439

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A283V	TCGA-AX-A2HD	UCEC	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.25
p.A283V	TCGA-CG-5728	STAD	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.25
p.A283V	DO38619	STAD	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.25
p.A283V	DO42608	UCEC	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.25
p.R287M	TCGA-DZ-6133	KIRP	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.8632
p.R287M	DO20762	KIRP	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.8632
p.R287K	TCGA-FW-A3R5	SKCM	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.7237
p.R287K	DO37406	SKCM	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.7237
p.R287K	SIDM01617	Endometrial Carcinoma	GDSC	EREKLRGIT	DEG_APCC_DBOX_1	0.7237
p.R287K	ACH-000994	Endometrial/Uterine Cancer	CCLE	EREKLRGIT	DEG_APCC_DBOX_1	0.7237
p.T304M	TCGA-HE-7130	KIRP	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.0556
p.T304M	DO20776	KIRP	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.0556
p.R291H	TCGA-KN-8428	KICH	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.7133
p.R291H	DO227709	COCA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.7133
p.R291H	DO220484	KICH	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.7133
p.P280S	TCGA-NC-A5HM	LUSC	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.1667
p.P280S	DO219195	LUSC	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.1667
p.T298I	TCGA-QC-A7B5	SARC	TCGA	EREKLRGIT	DEG_APCC_DBOX_1	0.2222
p.T298I	DO232224	PBCA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.2222
p.T298I	DO220239	SARC	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.2222
p.T279N	DO229009	LICA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.1389
p.E285K	DO220877	MELA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.3056
p.P280T	DO46438	OV	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.1667
p.N300S	DO232224	PBCA	ICGC	EREKLRGIT	DEG_APCC_DBOX_1	0.1667
p.R291C	SIDM00217	Colorectal Carcinoma	GDSC	EREKLRGIT	DEG_APCC_DBOX_1	0.719
p.R291C	SNU-1040	large_intestine	COSMIC	EREKLRGIT	DEG_APCC_DBOX_1	0.719
p.T278M	ACH-000419	Myeloma	CCLE	EREKLRGIT	DEG_APCC_DBOX_1	0.1111
p.T278M	ACH-001541	Myeloma	CCLE	EREKLRGIT	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EREKLRGIT

Degron related mutations and impact score

Drug responses associated with CALHM1 mutations

All proteins holding degron of EREKLRGIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IU99	Calcium homeostasis modulator protein 1	DEG_APCC_DBOX_1	286:294	EREKLRGIT	APC,CDC20,FZR1	0.9964	More...