DegronMD - Q8IUD2(ERC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1047S	TCGA-A7-A0D9	BRCA	TCGA	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation altering degron motif	0.6752
p.P1047S	DO4128	BRCA	ICGC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation altering degron motif	0.6752
p.G1044E	TCGA-CR-6470	HNSC	TCGA	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.3056
p.G1044E	DO14686	HNSC	ICGC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.3056
p.G1044V	TCGA-D1-A1O5	UCEC	TCGA	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.3056
p.G1044V	DO43426	UCEC	ICGC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.3056
p.R1037Q	TCGA-KK-A8IC	PRAD	TCGA	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1111
p.R1037Q	DO233766	GACA	ICGC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1111
p.R1037Q	DO219327	PRAD	ICGC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1111
p.R1043L	DO228976	LICA	ICGC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.2778
p.R1043L	ACH-001302	Neuroblastoma	CCLE	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.2778
p.R1043H	SIDM02026	Colorectal Carcinoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.2778
p.Q1057R	SIDM00629	Breast Carcinoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1389
p.Q1057R	SIDM01483	Melanoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1389
p.Q1057R	SIDM00244	Neuroblastoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1389
p.D1055N	SIDM01099	Neuroblastoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1944
p.D1055N	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1944
p.D1055N	SIDM00613	Glioblastoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1944
p.D1055N	SK-N-FI	autonomic ganglia	COSMIC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1944
p.D1055N	KALS-1	central nervous system	COSMIC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1944
p.D1055N	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1944
p.D1056E	ACH-000578	Lung Cancer	CCLE	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.1667
p.D1059N	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.0833
p.D1059N	SK-N-FI	autonomic ganglia	COSMIC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.0833
p.D1059N	KALS-1	central nervous system	COSMIC	LTPPAS	DEG_SCF_FBW7_1	1045:1050	Mutation rewiring degron network	0.0833

Kaplan plot for ERC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERC1

UniProt ID: Q8IUD2

Entrez ID: 23085

Protein name: ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERC1 in