DegronMD

Uniprot ID: Q8IUD2

Source protein: ELKS/Rab6-interacting/CAST family member 1

Source gene: ERC1

Class: DEG_SCF_FBW7_1

Location: 1045:1050

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 89.4333

COIL: 0.8528

CONS_SCORE: 0.463

DSS_SCORE: 0.3785

HELIX: 0.125

FCONS_SCORE: 0.9895

RIG_SCORE: 0.7263

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1047S	TCGA-A7-A0D9	BRCA	TCGA	LTPPAS	DEG_SCF_FBW7_1	0.6752
p.P1047S	DO4128	BRCA	ICGC	LTPPAS	DEG_SCF_FBW7_1	0.6752
p.G1044E	TCGA-CR-6470	HNSC	TCGA	LTPPAS	DEG_SCF_FBW7_1	0.3056
p.G1044E	DO14686	HNSC	ICGC	LTPPAS	DEG_SCF_FBW7_1	0.3056
p.G1044V	TCGA-D1-A1O5	UCEC	TCGA	LTPPAS	DEG_SCF_FBW7_1	0.3056
p.G1044V	DO43426	UCEC	ICGC	LTPPAS	DEG_SCF_FBW7_1	0.3056
p.R1037Q	TCGA-KK-A8IC	PRAD	TCGA	LTPPAS	DEG_SCF_FBW7_1	0.1111
p.R1037Q	DO233766	GACA	ICGC	LTPPAS	DEG_SCF_FBW7_1	0.1111
p.R1037Q	DO219327	PRAD	ICGC	LTPPAS	DEG_SCF_FBW7_1	0.1111
p.R1043L	DO228976	LICA	ICGC	LTPPAS	DEG_SCF_FBW7_1	0.2778
p.R1043L	ACH-001302	Neuroblastoma	CCLE	LTPPAS	DEG_SCF_FBW7_1	0.2778
p.R1043H	SIDM02026	Colorectal Carcinoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	0.2778
p.Q1057R	SIDM00629	Breast Carcinoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	0.1389
p.Q1057R	SIDM01483	Melanoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	0.1389
p.Q1057R	SIDM00244	Neuroblastoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	0.1389
p.D1055N	SIDM01099	Neuroblastoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	0.1944
p.D1055N	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LTPPAS	DEG_SCF_FBW7_1	0.1944
p.D1055N	SIDM00613	Glioblastoma	GDSC	LTPPAS	DEG_SCF_FBW7_1	0.1944
p.D1055N	SK-N-FI	autonomic_ganglia	COSMIC	LTPPAS	DEG_SCF_FBW7_1	0.1944
p.D1055N	KALS-1	central_nervous_system	COSMIC	LTPPAS	DEG_SCF_FBW7_1	0.1944
p.D1055N	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPAS	DEG_SCF_FBW7_1	0.1944
p.D1056E	ACH-000578	Lung Cancer	CCLE	LTPPAS	DEG_SCF_FBW7_1	0.1667
p.D1059N	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPAS	DEG_SCF_FBW7_1	0.0833
p.D1059N	SK-N-FI	autonomic_ganglia	COSMIC	LTPPAS	DEG_SCF_FBW7_1	0.0833
p.D1059N	KALS-1	central_nervous_system	COSMIC	LTPPAS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUD2	ELKS/Rab6-interacting/CAST family member 1	DEG_SCF_FBW7_1	1045:1050	LTPPAS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPPAS

Degron related mutations and impact score

Drug responses associated with ERC1 mutations

All proteins holding degron of LTPPAS