DegronMD - Q8IUL8(CILP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G971R	TCGA-90-A4ED	LUSC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.6457
p.G971R	DO45482	LUSC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.6457
p.R983H	TCGA-BR-6802	STAD	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0556
p.H962Q	TCGA-DI-A1BU	UCEC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.25
p.H962Q	DO42023	UCEC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.25
p.G971E	TCGA-EE-A29C	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.6087
p.R979Q	TCGA-EE-A3JD	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1667
p.R979Q	DO50299	SKCM	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1667
p.R964C	TCGA-EI-6507	READ	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.3056
p.R966C	TCGA-EY-A1G8	UCEC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R966C	TCGA-GS-A9TT	DLBC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R966C	DO219912	DLBC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R966C	DO43578	UCEC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.P981H	TCGA-FS-A1ZN	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.P981H	DO38165	SKCM	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.E982K	TCGA-OR-A5JR	ACC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0833
p.A958T	TCGA-VQ-A8P2	STAD	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.A958T	DO51761	STAD	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.A958T	ACH-001127	Leukemia	CCLE	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.P981L	TCGA-YG-AA3N	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1111
p.G967S	DO222800	COCA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.5882
p.R983C	DO233748	GACA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.0556
p.A975S	DO228188	LICA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.2778
p.A958S	DO228971	LICA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389
p.R970C	DO228375	MALY	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.R970C	DO36675	READ	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.8301
p.G977E	DO222727	MELA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.2222
p.G977E	DO38028	SKCM	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.2222
p.G967C	ACH-000179	Lung Cancer	CCLE	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation altering degron motif	0.6489
p.M958I	KP-3	pancreas	COSMIC	TRGQLYGLR	DEG_APCC_DBOX_1	965:973	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CILP2

UniProt ID: Q8IUL8

Entrez ID: 148113

Protein name: Cartilage intermediate layer protein 2 (CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CILP2 in