DegronMD

Uniprot ID: Q8IUL8

Source protein: Cartilage intermediate layer protein 2

Source gene: CILP2

Class: DEG_APCC_DBOX_1

Location: 965:973

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9943

ASA_SCORE: 61.1556

COIL: 0.6787

CONS_SCORE: 0.7785

DSS_SCORE: 0.6141

HELIX: 0.0403

FCONS_SCORE: 1.1933

RIG_SCORE: 0.7049

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G971R	TCGA-90-A4ED	LUSC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.6457
p.G971R	DO45482	LUSC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.6457
p.R983H	TCGA-BR-6802	STAD	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.0556
p.H962Q	TCGA-DI-A1BU	UCEC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.25
p.H962Q	DO42023	UCEC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.25
p.G971E	TCGA-EE-A29C	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.6087
p.R979Q	TCGA-EE-A3JD	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.1667
p.R979Q	DO50299	SKCM	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.1667
p.R964C	TCGA-EI-6507	READ	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.3056
p.R966C	TCGA-EY-A1G8	UCEC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.8301
p.R966C	TCGA-GS-A9TT	DLBC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.8301
p.R966C	DO219912	DLBC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.8301
p.R966C	DO43578	UCEC	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.8301
p.P981H	TCGA-FS-A1ZN	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.1111
p.P981H	DO38165	SKCM	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.1111
p.E982K	TCGA-OR-A5JR	ACC	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.0833
p.A958T	TCGA-VQ-A8P2	STAD	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.1389
p.A958T	DO51761	STAD	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.1389
p.A958T	ACH-001127	Leukemia	CCLE	TRGQLYGLR	DEG_APCC_DBOX_1	0.1389
p.P981L	TCGA-YG-AA3N	SKCM	TCGA	TRGQLYGLR	DEG_APCC_DBOX_1	0.1111
p.G967S	DO222800	COCA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.5882
p.R983C	DO233748	GACA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.0556
p.A975S	DO228188	LICA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.2778
p.A958S	DO228971	LICA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.1389
p.R970C	DO228375	MALY	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.8301
p.R970C	DO36675	READ	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.8301
p.G977E	DO222727	MELA	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.2222
p.G977E	DO38028	SKCM	ICGC	TRGQLYGLR	DEG_APCC_DBOX_1	0.2222
p.G967C	ACH-000179	Lung Cancer	CCLE	TRGQLYGLR	DEG_APCC_DBOX_1	0.6489
p.M958I	KP-3	pancreas	COSMIC	TRGQLYGLR	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRGQLYGLR

Degron related mutations and impact score

Drug responses associated with CILP2 mutations

All proteins holding degron of TRGQLYGLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUL8	Cartilage intermediate layer protein 2	DEG_APCC_DBOX_1	965:973	TRGQLYGLR	APC,CDC20,FZR1	0.9943	More...