DegronMD - Q8IUX8(EGFL6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E302K	TCGA-5L-AAT1	BRCA	TCGA	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.591
p.E302K	DO219594	BRCA	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.591
p.K293N	TCGA-78-7220	LUAD	TCGA	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation substituting flanking lysine	0.2778
p.K293N	DO24409	LUAD	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation substituting flanking lysine	0.2778
p.M290I	TCGA-DK-A3X1	BLCA	TCGA	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation rewiring degron network	0.0833
p.M290I	DO447	BLCA	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation rewiring degron network	0.0833
p.T300N	TCGA-EO-A3AV	UCEC	TCGA	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.7055
p.T300N	DO52412	UCEC	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.7055
p.P301R	TCGA-NJ-A55R	LUAD	TCGA	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.7512
p.P301R	DO218947	LUAD	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.7512
p.S289N	TCGA-UY-A78P	BLCA	TCGA	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation rewiring degron network	0.0556
p.S289N	DO219036	BLCA	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation rewiring degron network	0.0556
p.T304I	DO228217	LICA	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.7078
p.P303L	DO220866	MELA	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation altering degron motif	0.6471
p.K310Q	DO229435	PRAD	ICGC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation substituting flanking lysine	0.2778
p.K292N	SIDM01190	Bladder Carcinoma	GDSC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation substituting flanking lysine	0.25
p.K292N	ACH-000720	Bladder Cancer	CCLE	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation substituting flanking lysine	0.25
p.K292N	TCCSUP	urinary tract	COSMIC	VTPEPT	DEG_SCF_FBW7_1	299:304	Mutation substituting flanking lysine	0.25

Kaplan plot for EGFL6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EGFL6

UniProt ID: Q8IUX8

Entrez ID: 25975

Protein name: Epidermal growth factor-like protein 6 (EGF-like protein 6) (MAM and EGF domains-containing gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EGFL6 in