DegronMD

Uniprot ID: Q8IUX8

Source protein: Epidermal growth factor-like protein 6

Source gene: EGFL6

Class: DEG_SCF_FBW7_1

Location: 299:304

E3 ligase: FBXW7

DEGRON score: 0.977

ASA_SCORE: 85.7833

COIL: 0.8712

CONS_SCORE: 0.6695

DSS_SCORE: 0.6629

HELIX: 0.0355

FCONS_SCORE: 1.2503

RIG_SCORE: 0.6679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E302K	TCGA-5L-AAT1	BRCA	TCGA	VTPEPT	DEG_SCF_FBW7_1	0.591
p.E302K	DO219594	BRCA	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.591
p.K293N	TCGA-78-7220	LUAD	TCGA	VTPEPT	DEG_SCF_FBW7_1	0.2778
p.K293N	DO24409	LUAD	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.2778
p.M290I	TCGA-DK-A3X1	BLCA	TCGA	VTPEPT	DEG_SCF_FBW7_1	0.0833
p.M290I	DO447	BLCA	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.0833
p.T300N	TCGA-EO-A3AV	UCEC	TCGA	VTPEPT	DEG_SCF_FBW7_1	0.7055
p.T300N	DO52412	UCEC	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.7055
p.P301R	TCGA-NJ-A55R	LUAD	TCGA	VTPEPT	DEG_SCF_FBW7_1	0.7512
p.P301R	DO218947	LUAD	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.7512
p.S289N	TCGA-UY-A78P	BLCA	TCGA	VTPEPT	DEG_SCF_FBW7_1	0.0556
p.S289N	DO219036	BLCA	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.0556
p.T304I	DO228217	LICA	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.7078
p.P303L	DO220866	MELA	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.6471
p.K310Q	DO229435	PRAD	ICGC	VTPEPT	DEG_SCF_FBW7_1	0.2778
p.K292N	SIDM01190	Bladder Carcinoma	GDSC	VTPEPT	DEG_SCF_FBW7_1	0.25
p.K292N	ACH-000720	Bladder Cancer	CCLE	VTPEPT	DEG_SCF_FBW7_1	0.25
p.K292N	TCCSUP	urinary_tract	COSMIC	VTPEPT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUX8	Epidermal growth factor-like protein 6	DEG_SCF_FBW7_1	299:304	VTPEPT	FBXW7	0.977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons