DegronMD - Q8IV32(CCDC71)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R104L	TCGA-86-7701	LUAD	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1111
p.R104L	DO24441	LUAD	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1111
p.A126V	TCGA-AP-A051	UCEC	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1667
p.A126V	DO42673	UCEC	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1667
p.T115S	TCGA-BT-A3PJ	BLCA	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation altering degron motif	0.7116
p.T115S	DO44097	BLCA	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation altering degron motif	0.7116
p.R124K	TCGA-D5-6927	COAD	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.2222
p.R124K	DO10332	COAD	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.2222
p.R108Q	TCGA-HU-A4G3	STAD	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.2222
p.R108Q	DO47807	STAD	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.2222
p.M119T	DO48414	BLCA	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation altering degron motif	0.7423
p.A106D	DO229037	LICA	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1667
p.M107V	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1944
p.M107V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	GRATLLPMP	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1944

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons