DegronMD

Uniprot ID: Q8IV32

Source protein: Coiled-coil domain-containing protein 71

Source gene: CCDC71

Class: DEG_APCC_DBOX_1

Location: 112:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8201

ASA_SCORE: 82.5667

COIL: 0.7373

CONS_SCORE: 0.5289

DSS_SCORE: 0.5067

HELIX: 0.2168

FCONS_SCORE: 0.9298

RIG_SCORE: 0.7284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R104L	TCGA-86-7701	LUAD	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	0.1111
p.R104L	DO24441	LUAD	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	0.1111
p.A126V	TCGA-AP-A051	UCEC	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	0.1667
p.A126V	DO42673	UCEC	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	0.1667
p.T115S	TCGA-BT-A3PJ	BLCA	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	0.7116
p.T115S	DO44097	BLCA	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	0.7116
p.R124K	TCGA-D5-6927	COAD	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	0.2222
p.R124K	DO10332	COAD	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	0.2222
p.R108Q	TCGA-HU-A4G3	STAD	TCGA	GRATLLPMP	DEG_APCC_DBOX_1	0.2222
p.R108Q	DO47807	STAD	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	0.2222
p.M119T	DO48414	BLCA	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	0.7423
p.A106D	DO229037	LICA	ICGC	GRATLLPMP	DEG_APCC_DBOX_1	0.1667
p.M107V	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	GRATLLPMP	DEG_APCC_DBOX_1	0.1944
p.M107V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	GRATLLPMP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV32	Coiled-coil domain-containing protein 71	DEG_APCC_DBOX_1	112:120	GRATLLPMP	APC,CDC20,FZR1	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons