DegronMD - Q8IV33(KIAA0825)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1262I	TCGA-AP-A059	UCEC	TCGA	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.7078
p.T1262I	DO41361	UCEC	ICGC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.7078
p.S1267Y	TCGA-B5-A11E	UCEC	TCGA	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation rewiring degron network	0.3056
p.S1267Y	DO41644	UCEC	ICGC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation rewiring degron network	0.3056
p.S1266F	TCGA-C5-A902	CESC	TCGA	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.7982
p.S1266F	DO49916	CESC	ICGC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.7982
p.H1256R	DO1127	BRCA	ICGC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation rewiring degron network	0.2222
p.T1262N	DO229015	LICA	ICGC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.7055
p.Q1275L	SIDM01183	Other Solid Cancers	GDSC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation rewiring degron network	0.0833
p.Q1275L	ACH-001417	Lung Cancer	CCLE	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation rewiring degron network	0.0833
p.Q1275L	UMC-11	lung	COSMIC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation rewiring degron network	0.0833
p.Q1264L	SIDM00796	Head and Neck Carcinoma	GDSC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.6654
p.Q1264L	ACH-000740	Head and Neck Cancer	CCLE	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.6654
p.Q1264L	A253	salivary gland	COSMIC	ICTPQNS	DEG_SCF_FBW7_1	1260:1266	Mutation altering degron motif	0.6654

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons