DegronMD

Uniprot ID: Q8IV33

Source protein: Uncharacterized protein KIAA0825

Source gene: KIAA0825

Class: DEG_SCF_FBW7_1

Location: 1260:1266

E3 ligase: FBXW7

DEGRON score: 0.9897

ASA_SCORE: 80.3143

COIL: 0.8274

CONS_SCORE: 0.2861

DSS_SCORE: 0.5274

HELIX: 0.1603

FCONS_SCORE: 1.0634

RIG_SCORE: 0.696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1262I	TCGA-AP-A059	UCEC	TCGA	ICTPQNS	DEG_SCF_FBW7_1	0.7078
p.T1262I	DO41361	UCEC	ICGC	ICTPQNS	DEG_SCF_FBW7_1	0.7078
p.S1267Y	TCGA-B5-A11E	UCEC	TCGA	ICTPQNS	DEG_SCF_FBW7_1	0.3056
p.S1267Y	DO41644	UCEC	ICGC	ICTPQNS	DEG_SCF_FBW7_1	0.3056
p.S1266F	TCGA-C5-A902	CESC	TCGA	ICTPQNS	DEG_SCF_FBW7_1	0.7982
p.S1266F	DO49916	CESC	ICGC	ICTPQNS	DEG_SCF_FBW7_1	0.7982
p.H1256R	DO1127	BRCA	ICGC	ICTPQNS	DEG_SCF_FBW7_1	0.2222
p.T1262N	DO229015	LICA	ICGC	ICTPQNS	DEG_SCF_FBW7_1	0.7055
p.Q1275L	SIDM01183	Other Solid Cancers	GDSC	ICTPQNS	DEG_SCF_FBW7_1	0.0833
p.Q1275L	ACH-001417	Lung Cancer	CCLE	ICTPQNS	DEG_SCF_FBW7_1	0.0833
p.Q1275L	UMC-11	lung	COSMIC	ICTPQNS	DEG_SCF_FBW7_1	0.0833
p.Q1264L	SIDM00796	Head and Neck Carcinoma	GDSC	ICTPQNS	DEG_SCF_FBW7_1	0.6654
p.Q1264L	ACH-000740	Head and Neck Cancer	CCLE	ICTPQNS	DEG_SCF_FBW7_1	0.6654
p.Q1264L	A253	salivary_gland	COSMIC	ICTPQNS	DEG_SCF_FBW7_1	0.6654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV33	Uncharacterized protein KIAA0825	DEG_SCF_FBW7_1	1260:1266	ICTPQNS	FBXW7	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons