DegronMD - Q8IV61(RASGRP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D627Y	TCGA-22-5473	LUSC	TCGA	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.7325
p.D627Y	DO26467	LUSC	ICGC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.7325
p.E622D	TCGA-29-1711	OV	TCGA	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.1944
p.E622D	DO30630	OV	ICGC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.1944
p.E617D	TCGA-37-4133	LUSC	TCGA	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.0556
p.E617D	DO26465	LUSC	ICGC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.0556
p.E617K	TCGA-BF-AAP6	SKCM	TCGA	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.0556
p.E617K	DO219470	SKCM	ICGC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.0556
p.G629E	TCGA-FW-A3R5	SKCM	TCGA	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.7199
p.G629E	DO37406	SKCM	ICGC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.7199
p.M636I	DO229453	SKCA	ICGC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.M636I	SIDM00007	Other Solid Cancers	GDSC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.M636I	SIDM00890	Melanoma	GDSC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.M636I	ACH-000580	Skin Cancer	CCLE	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.M636I	ACH-001550	Skin Cancer	CCLE	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.M636I	C32	skin	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.S630P	DO42673	UCEC	ICGC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.5641
p.M636L	SIDM00074	Burkitt's Lymphoma	GDSC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.M636L	ACH-000402	Lymphoma	CCLE	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.M636L	BL-70	haematopoietic and lymphoid tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.2222
p.D627E	SIDM00370	T-Lymphoblastic Leukemia	GDSC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.6758
p.D627E	ACH-000197	Leukemia	CCLE	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.6758
p.D627E	TALL-1	haematopoietic and lymphoid tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation altering degron motif	0.6758
p.M635I	C32	skin	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation substituting flanking lysine	0.3611
p.D626E	TALL-1	haematopoietic and lymphoid tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation rewiring degron network	0.3056
p.M635L	BL-70	haematopoietic and lymphoid tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	627:632	Mutation substituting flanking lysine	0.3611

Kaplan plot for RASGRP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASGRP3

UniProt ID: Q8IV61

Entrez ID: 25780

Protein name: Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASGRP3 in