DegronMD

Uniprot ID: Q8IV61

Source protein: Ras guanyl-releasing protein 3

Source gene: RASGRP3

Class: DEG_SCF_TRCP1_1

Location: 627:632

E3 ligase: BTRC

DEGRON score: 0.9994

ASA_SCORE: 68.0667

COIL: 0.8012

CONS_SCORE: 0.4752

DSS_SCORE: 0.4935

HELIX: 0.1212

FCONS_SCORE: 1.0431

RIG_SCORE: 0.6337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D627Y	TCGA-22-5473	LUSC	TCGA	DSGSHT	DEG_SCF_TRCP1_1	0.7325
p.D627Y	DO26467	LUSC	ICGC	DSGSHT	DEG_SCF_TRCP1_1	0.7325
p.E622D	TCGA-29-1711	OV	TCGA	DSGSHT	DEG_SCF_TRCP1_1	0.1944
p.E622D	DO30630	OV	ICGC	DSGSHT	DEG_SCF_TRCP1_1	0.1944
p.E617D	TCGA-37-4133	LUSC	TCGA	DSGSHT	DEG_SCF_TRCP1_1	0.0556
p.E617D	DO26465	LUSC	ICGC	DSGSHT	DEG_SCF_TRCP1_1	0.0556
p.E617K	TCGA-BF-AAP6	SKCM	TCGA	DSGSHT	DEG_SCF_TRCP1_1	0.0556
p.E617K	DO219470	SKCM	ICGC	DSGSHT	DEG_SCF_TRCP1_1	0.0556
p.G629E	TCGA-FW-A3R5	SKCM	TCGA	DSGSHT	DEG_SCF_TRCP1_1	0.7199
p.G629E	DO37406	SKCM	ICGC	DSGSHT	DEG_SCF_TRCP1_1	0.7199
p.M636I	DO229453	SKCA	ICGC	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.M636I	SIDM00007	Other Solid Cancers	GDSC	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.M636I	SIDM00890	Melanoma	GDSC	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.M636I	ACH-000580	Skin Cancer	CCLE	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.M636I	ACH-001550	Skin Cancer	CCLE	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.M636I	C32	skin	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.S630P	DO42673	UCEC	ICGC	DSGSHT	DEG_SCF_TRCP1_1	0.5641
p.M636L	SIDM00074	Burkitt's Lymphoma	GDSC	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.M636L	ACH-000402	Lymphoma	CCLE	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.M636L	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	0.2222
p.D627E	SIDM00370	T-Lymphoblastic Leukemia	GDSC	DSGSHT	DEG_SCF_TRCP1_1	0.6758
p.D627E	ACH-000197	Leukemia	CCLE	DSGSHT	DEG_SCF_TRCP1_1	0.6758
p.D627E	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	0.6758
p.M635I	C32	skin	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	0.3611
p.D626E	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	0.3056
p.M635L	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHT	DEG_SCF_TRCP1_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV61	Ras guanyl-releasing protein 3	DEG_SCF_TRCP1_1	627:632	DSGSHT	BTRC	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSHT

Degron related mutations and impact score

Drug responses associated with RASGRP3 mutations

All proteins holding degron of DSGSHT