DegronMD - Q8IVF1(NUTM2A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E189K	TCGA-21-1079	LUSC	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.3056
p.E189K	DO26846	LUSC	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.3056
p.G173C	TCGA-AA-3984	COAD	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.G173C	DO9002	COAD	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.G173D	TCGA-B5-A3FC	UCEC	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.G173D	DO41871	UCEC	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.P171S	TCGA-D3-A8GM	SKCM	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.P171S	DO50288	SKCM	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.P171S	ACH-000987	Skin Cancer	CCLE	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.P171S	Mewo	skin	COSMIC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.G194D	TCGA-EE-A2M5	SKCM	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1667
p.G194D	DO37425	SKCM	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1667
p.G197R	TCGA-ER-A195	SKCM	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0833
p.G197R	DO229470	SKCA	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0833
p.G197R	DO47712	SKCM	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0833
p.L186M	TCGA-LT-A5Z6	BLCA	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.5999
p.L186M	DO44029	BLCA	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.5999
p.Q190H	SIDM00980	Gastric Carcinoma	GDSC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2778
p.Q190H	ACH-000948	Gastric Cancer	CCLE	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2778
p.Q190H	23132-87	stomach	COSMIC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2778
p.L186V	SIDM01398	Melanoma	GDSC	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.5654
p.L186V	ACH-000661	Skin Cancer	CCLE	LPSTPLVT	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.5654

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUTM2A

UniProt ID: Q8IVF1

Entrez ID: 728118

Protein name: NUT family member 2A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUTM2A in