DegronMD

Uniprot ID: Q8IVF1

Source protein: NUT family member 2A

Source gene: NUTM2A

Class: DEG_SCF_FBW7_1

Location: 181:188

E3 ligase: FBXW7

DEGRON score: 0.8216

ASA_SCORE: 43.0375

COIL: 0.7406

CONS_SCORE: 0.4599

DSS_SCORE: 0.5272

HELIX: 0.0576

FCONS_SCORE: 1.0236

RIG_SCORE: 0.7381

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E189K	TCGA-21-1079	LUSC	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	0.3056
p.E189K	DO26846	LUSC	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.3056
p.G173C	TCGA-AA-3984	COAD	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	0.1111
p.G173C	DO9002	COAD	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.1111
p.G173D	TCGA-B5-A3FC	UCEC	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	0.1111
p.G173D	DO41871	UCEC	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.1111
p.P171S	TCGA-D3-A8GM	SKCM	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	0.0556
p.P171S	DO50288	SKCM	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.0556
p.P171S	ACH-000987	Skin Cancer	CCLE	LPSTPLVT	DEG_SCF_FBW7_1	0.0556
p.P171S	Mewo	skin	COSMIC	LPSTPLVT	DEG_SCF_FBW7_1	0.0556
p.G194D	TCGA-EE-A2M5	SKCM	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	0.1667
p.G194D	DO37425	SKCM	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.1667
p.G197R	TCGA-ER-A195	SKCM	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	0.0833
p.G197R	DO229470	SKCA	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.0833
p.G197R	DO47712	SKCM	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.0833
p.L186M	TCGA-LT-A5Z6	BLCA	TCGA	LPSTPLVT	DEG_SCF_FBW7_1	0.5999
p.L186M	DO44029	BLCA	ICGC	LPSTPLVT	DEG_SCF_FBW7_1	0.5999
p.Q190H	SIDM00980	Gastric Carcinoma	GDSC	LPSTPLVT	DEG_SCF_FBW7_1	0.2778
p.Q190H	ACH-000948	Gastric Cancer	CCLE	LPSTPLVT	DEG_SCF_FBW7_1	0.2778
p.Q190H	23132-87	stomach	COSMIC	LPSTPLVT	DEG_SCF_FBW7_1	0.2778
p.L186V	SIDM01398	Melanoma	GDSC	LPSTPLVT	DEG_SCF_FBW7_1	0.5654
p.L186V	ACH-000661	Skin Cancer	CCLE	LPSTPLVT	DEG_SCF_FBW7_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF1	NUT family member 2A	DEG_SCF_FBW7_1	181:188	LPSTPLVT	FBXW7	0.8216	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons