DegronMD - Q8IVF7(FMNL3)

FMNL3

UniProt ID: Q8IVF7

Entrez ID: 91010

Protein name: Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P522S	TCGA-73-4662	LUAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2222
p.P522S	DO24790	LUAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2222
p.P508A	TCGA-98-8021	LUSC	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.7503
p.P508A	DO27468	LUSC	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.7503
p.E513K	TCGA-AC-A23H	BRCA	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.591
p.E513K	DO2401	BRCA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.591
p.P508T	TCGA-AM-5821	COAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.7031
p.P508T	DO8240	COAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.7031
p.D502G	TCGA-AX-A0J0	UCEC	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2222
p.D502G	DO41133	UCEC	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2222
p.P512L	TCGA-CD-A4MG	STAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.6471
p.P512L	DO227646	COCA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.6471
p.P512L	DO48009	STAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.6471
p.P524Q	TCGA-D3-A1Q6	SKCM	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1667
p.P524Q	TCGA-GF-A2C7	SKCM	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1667
p.P524Q	DO37407	SKCM	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1667
p.P524Q	DO37450	SKCM	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1667
p.P499S	TCGA-DH-A7UR	LGG	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1389
p.P499S	DO51809	LGG	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1389
p.P520L	TCGA-EE-A182	SKCM	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2778
p.P520L	DO37814	SKCM	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2778
p.P525L	TCGA-XK-AAIW	PRAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1389
p.P525L	DO51407	PRAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1389
p.D502N	DO50436	ESAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2222
p.E513D	DO233636	GACA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.5647
p.P499T	DO229034	LICA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.1389
p.P522A	DO46473	OV	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.2222
p.A507V	DO42673	UCEC	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation altering degron motif	0.6936
p.R519Q	ACH-002349	Non-Cancerous	CCLE	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	506:518	Mutation rewiring degron network	0.3056

Kaplan plot for FMNL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc