DegronMD

Uniprot ID: Q8IVF7

Source protein: Formin-like protein 3

Source gene: FMNL3

Class: DEG_ODPH_VHL_1

Location: 506:518

E3 ligase: VHL

DEGRON score: 0.9312

ASA_SCORE: 84.4538

COIL: 0.9305

CONS_SCORE: 0.5036

DSS_SCORE: 0.6731

HELIX: 0.0435

FCONS_SCORE: 0.9215

RIG_SCORE: 0.56

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P522S	TCGA-73-4662	LUAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2222
p.P522S	DO24790	LUAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2222
p.P508A	TCGA-98-8021	LUSC	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.7503
p.P508A	DO27468	LUSC	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.7503
p.E513K	TCGA-AC-A23H	BRCA	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.591
p.E513K	DO2401	BRCA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.591
p.P508T	TCGA-AM-5821	COAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.7031
p.P508T	DO8240	COAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.7031
p.D502G	TCGA-AX-A0J0	UCEC	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2222
p.D502G	DO41133	UCEC	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2222
p.P512L	TCGA-CD-A4MG	STAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.6471
p.P512L	DO227646	COCA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.6471
p.P512L	DO48009	STAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.6471
p.P524Q	TCGA-D3-A1Q6	SKCM	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1667
p.P524Q	TCGA-GF-A2C7	SKCM	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1667
p.P524Q	DO37407	SKCM	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1667
p.P524Q	DO37450	SKCM	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1667
p.P499S	TCGA-DH-A7UR	LGG	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1389
p.P499S	DO51809	LGG	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1389
p.P520L	TCGA-EE-A182	SKCM	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2778
p.P520L	DO37814	SKCM	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2778
p.P525L	TCGA-XK-AAIW	PRAD	TCGA	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1389
p.P525L	DO51407	PRAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1389
p.D502N	DO50436	ESAD	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2222
p.E513D	DO233636	GACA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.5647
p.P499T	DO229034	LICA	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.1389
p.P522A	DO46473	OV	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.2222
p.A507V	DO42673	UCEC	ICGC	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.6936
p.R519Q	ACH-002349	Non-Cancerous	CCLE	LAPAPPPEEVLPL	DEG_ODPH_VHL_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPAPPPEEVLPL

Degron related mutations and impact score

Drug responses associated with FMNL3 mutations

All proteins holding degron of LAPAPPPEEVLPL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF7	Formin-like protein 3	DEG_ODPH_VHL_1	506:518	LAPAPPPEEVLPL	VHL	0.9312	More...