DegronMD - Q8IVL6(P3H3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C588Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.25
p.R599Q	SIDM00879	Breast Carcinoma	GDSC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.25
p.R599Q	HCC1500	breast	COSMIC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.25
p.P602T	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.1667
p.P602T	NCI-H441	lung	COSMIC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.1667
p.A585V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.1667
p.A585V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.1667
p.A603S	SIDM01664	Prostate Carcinoma	GDSC	DPDTGE	DEG_Kelch_Keap1_1	591:596	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons