DegronMD

Uniprot ID: Q8IVL6

Source protein: Prolyl 3-hydroxylase 3

Source gene: P3H3

Class: DEG_Kelch_Keap1_1

Location: 591:596

E3 ligase: KEAP1

DEGRON score: 0.7405

ASA_SCORE: 64.7167

COIL: 0.8515

CONS_SCORE: 0.333

DSS_SCORE: 0.3254

HELIX: 0.0358

FCONS_SCORE: 0.7331

RIG_SCORE: 0.7386

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C588Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DPDTGE	DEG_Kelch_Keap1_1	0.25
p.R599Q	SIDM00879	Breast Carcinoma	GDSC	DPDTGE	DEG_Kelch_Keap1_1	0.25
p.R599Q	HCC1500	breast	COSMIC	DPDTGE	DEG_Kelch_Keap1_1	0.25
p.P602T	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	DPDTGE	DEG_Kelch_Keap1_1	0.1667
p.P602T	NCI-H441	lung	COSMIC	DPDTGE	DEG_Kelch_Keap1_1	0.1667
p.A585V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DPDTGE	DEG_Kelch_Keap1_1	0.1667
p.A585V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DPDTGE	DEG_Kelch_Keap1_1	0.1667
p.A603S	SIDM01664	Prostate Carcinoma	GDSC	DPDTGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVL6	Prolyl 3-hydroxylase 3	DEG_Kelch_Keap1_1	591:596	DPDTGE	KEAP1	0.7405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons