DegronMD - Q8IW19(APLF)

APLF

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G148R	TCGA-AZ-4315	COAD	TCGA	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.0833
p.G148R	DO8842	COAD	ICGC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.0833
p.L166I	TCGA-D9-A148	SKCM	TCGA	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.2222
p.L166I	DO37971	SKCM	ICGC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.2222
p.N169D	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.1389
p.N169D	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.1389
p.N169D	SIDM00313	Hodgkin's Lymphoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.1389
p.N169D	SIDM01105	Melanoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.1389
p.S162C	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation altering degron motif	0.7541
p.S162C	ACH-000744	Lung Cancer	CCLE	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation altering degron motif	0.7541
p.S162C	NCI-H1623	lung	COSMIC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation altering degron motif	0.7541
p.L148F	OS-RC-2	kidney	COSMIC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.0833
p.L148F	SNU-81	large intestine	COSMIC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.0833
p.H168Y	SK-MEL-2	skin	COSMIC	MTPTNS	DEG_SCF_FBW7_1	157:162	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc