DegronMD

Uniprot ID: Q8IW19

Source protein: Aprataxin and PNK-like factor

Source gene: APLF

Class: DEG_SCF_FBW7_1

Location: 157:162

E3 ligase: FBXW7

DEGRON score: 0.5316

ASA_SCORE: 88.4667

COIL: 0.814

CONS_SCORE: 0.3068

DSS_SCORE: 0.5373

HELIX: 0.1338

FCONS_SCORE: 0.9286

RIG_SCORE: 0.706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G148R	TCGA-AZ-4315	COAD	TCGA	MTPTNS	DEG_SCF_FBW7_1	0.0833
p.G148R	DO8842	COAD	ICGC	MTPTNS	DEG_SCF_FBW7_1	0.0833
p.L166I	TCGA-D9-A148	SKCM	TCGA	MTPTNS	DEG_SCF_FBW7_1	0.2222
p.L166I	DO37971	SKCM	ICGC	MTPTNS	DEG_SCF_FBW7_1	0.2222
p.N169D	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	0.1389
p.N169D	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	0.1389
p.N169D	SIDM00313	Hodgkin's Lymphoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	0.1389
p.N169D	SIDM01105	Melanoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	0.1389
p.S162C	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	MTPTNS	DEG_SCF_FBW7_1	0.7541
p.S162C	ACH-000744	Lung Cancer	CCLE	MTPTNS	DEG_SCF_FBW7_1	0.7541
p.S162C	NCI-H1623	lung	COSMIC	MTPTNS	DEG_SCF_FBW7_1	0.7541
p.L148F	OS-RC-2	kidney	COSMIC	MTPTNS	DEG_SCF_FBW7_1	0.0833
p.L148F	SNU-81	large_intestine	COSMIC	MTPTNS	DEG_SCF_FBW7_1	0.0833
p.H168Y	SK-MEL-2	skin	COSMIC	MTPTNS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IW19	Aprataxin and PNK-like factor	DEG_SCF_FBW7_1	157:162	MTPTNS	FBXW7	0.5316	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons