DegronMD - Q8IW93(ARHGEF19)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S617N	TCGA-14-1794	GBM	TCGA	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1944
p.S617N	DO13024	GBM	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1944
p.L629F	TCGA-55-7724	LUAD	TCGA	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.2778
p.L629F	DO45373	LUAD	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.2778
p.L615Q	TCGA-EE-A3JA	SKCM	TCGA	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.L615Q	DO47625	SKCM	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.E636K	TCGA-GC-A3OO	BLCA	TCGA	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.0833
p.E636K	DO518	BLCA	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.0833
p.L622R	TCGA-HF-7133	STAD	TCGA	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation altering degron motif	0.8428
p.L622R	DO38819	STAD	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation altering degron motif	0.8428
p.L615M	TCGA-IB-7651	PAAD	TCGA	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.L615M	DO46657	PAAD	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.R633Q	DO234285	ESAD	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1667
p.R634Q	DO222444	ESCA	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.R634Q	SIDM01378	Ovarian Carcinoma	GDSC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.R634Q	ACH-000646	Ovarian Cancer	CCLE	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.L613P	DO229224	THCA	ICGC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.0833
p.R634W	SIDM00499	Prostate Carcinoma	GDSC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.R634W	SIDM00869	Non-Cancerous	GDSC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389
p.R634W	SIDM00271	Gastric Carcinoma	GDSC	LHLFND	LIG_APCC_ABBA_1	622:627	Mutation rewiring degron network	0.1389

Kaplan plot for ARHGEF19 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF19

UniProt ID: Q8IW93

Entrez ID: 128272

Protein name: Rho guanine nucleotide exchange factor 19 (Ephexin-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGEF19 in