DegronMD

Uniprot ID: Q8IW93

Source protein: Rho guanine nucleotide exchange factor 19

Source gene: ARHGEF19

Class: LIG_APCC_ABBA_1

Location: 622:627

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7214

ASA_SCORE: 8.1333

COIL: 0.3975

CONS_SCORE: 0.5755

DSS_SCORE: 0.0157

HELIX: 0.0092

FCONS_SCORE: 1.3798

RIG_SCORE: 0.9472

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S617N	TCGA-14-1794	GBM	TCGA	LHLFND	LIG_APCC_ABBA_1	0.1944
p.S617N	DO13024	GBM	ICGC	LHLFND	LIG_APCC_ABBA_1	0.1944
p.L629F	TCGA-55-7724	LUAD	TCGA	LHLFND	LIG_APCC_ABBA_1	0.2778
p.L629F	DO45373	LUAD	ICGC	LHLFND	LIG_APCC_ABBA_1	0.2778
p.L615Q	TCGA-EE-A3JA	SKCM	TCGA	LHLFND	LIG_APCC_ABBA_1	0.1389
p.L615Q	DO47625	SKCM	ICGC	LHLFND	LIG_APCC_ABBA_1	0.1389
p.E636K	TCGA-GC-A3OO	BLCA	TCGA	LHLFND	LIG_APCC_ABBA_1	0.0833
p.E636K	DO518	BLCA	ICGC	LHLFND	LIG_APCC_ABBA_1	0.0833
p.L622R	TCGA-HF-7133	STAD	TCGA	LHLFND	LIG_APCC_ABBA_1	0.8428
p.L622R	DO38819	STAD	ICGC	LHLFND	LIG_APCC_ABBA_1	0.8428
p.L615M	TCGA-IB-7651	PAAD	TCGA	LHLFND	LIG_APCC_ABBA_1	0.1389
p.L615M	DO46657	PAAD	ICGC	LHLFND	LIG_APCC_ABBA_1	0.1389
p.R633Q	DO234285	ESAD	ICGC	LHLFND	LIG_APCC_ABBA_1	0.1667
p.R634Q	DO222444	ESCA	ICGC	LHLFND	LIG_APCC_ABBA_1	0.1389
p.R634Q	SIDM01378	Ovarian Carcinoma	GDSC	LHLFND	LIG_APCC_ABBA_1	0.1389
p.R634Q	ACH-000646	Ovarian Cancer	CCLE	LHLFND	LIG_APCC_ABBA_1	0.1389
p.L613P	DO229224	THCA	ICGC	LHLFND	LIG_APCC_ABBA_1	0.0833
p.R634W	SIDM00499	Prostate Carcinoma	GDSC	LHLFND	LIG_APCC_ABBA_1	0.1389
p.R634W	SIDM00869	Non-Cancerous	GDSC	LHLFND	LIG_APCC_ABBA_1	0.1389
p.R634W	SIDM00271	Gastric Carcinoma	GDSC	LHLFND	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12774	Rho guanine nucleotide exchange factor 5	LIG_APCC_ABBA_1	1419:1424	LHLFND	APC,CDC20,FZR1	0.5856	More...
Q8IW93	Rho guanine nucleotide exchange factor 19	LIG_APCC_ABBA_1	622:627	LHLFND	APC,CDC20,FZR1	0.7214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons