DegronMD - Q12774(ARHGEF5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1412P	TCGA-06-5416	GBM	TCGA	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.1389
p.R1410G	TCGA-22-A5C4	LUSC	TCGA	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.0833
p.R1409Q	TCGA-AJ-A3TW	UCEC	TCGA	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.0556
p.T1414M	TCGA-B5-A1MW	UCEC	TCGA	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.1944
p.H1418Y	TCGA-VR-A8EY	ESCA	TCGA	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.3056
p.H505R	DO5298	BRCA	ICGC	VTPPRT	DEG_SCF_FBW7_1	509:514	Mutation rewiring degron network	0.2222
p.R506G	DO29538	OV	ICGC	VTPPRT	DEG_SCF_FBW7_1	509:514	Mutation rewiring degron network	0.25
p.A504P	DO41097	UCEC	ICGC	VTPPRT	DEG_SCF_FBW7_1	509:514	Mutation rewiring degron network	0.1944
p.L514M	DO41361	UCEC	ICGC	VTPPRT	DEG_SCF_FBW7_1	509:514	Mutation altering degron motif	0.711
p.G499E	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	VTPPRT	DEG_SCF_FBW7_1	509:514	Mutation rewiring degron network	0.0556
p.R1415C	ACH-000957	Colon/Colorectal Cancer	CCLE	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.2222
p.R1430Q	ACH-000971	Colon/Colorectal Cancer	CCLE	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.1667
p.P790H	ACH-000998	Colon/Colorectal Cancer	CCLE	LPSTPDSS	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.3056
p.R1415H	SK-GT-2	stomach	COSMIC	LHLFND	LIG_APCC_ABBA_1	1419:1424	Mutation rewiring degron network	0.2222
p.A504D	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	VTPPRT	DEG_SCF_FBW7_1	509:514	Mutation rewiring degron network	0.1944
p.V502L	GCT	soft tissue	COSMIC	VTPPRT	DEG_SCF_FBW7_1	509:514	Mutation rewiring degron network	0.1389

Kaplan plot for ARHGEF5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF5

UniProt ID: Q12774

Entrez ID: 7984

Protein name: Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF5 in