DegronMD

Uniprot ID: Q12774

Source protein: Rho guanine nucleotide exchange factor 5

Source gene: ARHGEF5

Class: LIG_APCC_ABBA_1

Location: 1419:1424

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5856

ASA_SCORE: 14.6

COIL: 0.3832

CONS_SCORE: 0.6615

DSS_SCORE: 0.0985

HELIX: 0.0255

FCONS_SCORE: 1.3889

RIG_SCORE: 0.8965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1412P	TCGA-06-5416	GBM	TCGA	LHLFND	LIG_APCC_ABBA_1	0.1389
p.R1410G	TCGA-22-A5C4	LUSC	TCGA	LHLFND	LIG_APCC_ABBA_1	0.0833
p.R1409Q	TCGA-AJ-A3TW	UCEC	TCGA	LHLFND	LIG_APCC_ABBA_1	0.0556
p.T1414M	TCGA-B5-A1MW	UCEC	TCGA	LHLFND	LIG_APCC_ABBA_1	0.1944
p.H1418Y	TCGA-VR-A8EY	ESCA	TCGA	LHLFND	LIG_APCC_ABBA_1	0.3056
p.R1415C	ACH-000957	Colon/Colorectal Cancer	CCLE	LHLFND	LIG_APCC_ABBA_1	0.2222
p.R1430Q	ACH-000971	Colon/Colorectal Cancer	CCLE	LHLFND	LIG_APCC_ABBA_1	0.1667
p.R1415H	SK-GT-2	stomach	COSMIC	LHLFND	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12774	Rho guanine nucleotide exchange factor 5	LIG_APCC_ABBA_1	1419:1424	LHLFND	APC,CDC20,FZR1	0.5856	More...
Q8IW93	Rho guanine nucleotide exchange factor 19	LIG_APCC_ABBA_1	622:627	LHLFND	APC,CDC20,FZR1	0.7214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons