DegronMD

Uniprot ID: Q12774

Source protein: Rho guanine nucleotide exchange factor 5

Source gene: ARHGEF5

Class: DEG_SCF_FBW7_1

Location: 791:798

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 82.7875

COIL: 0.9106

CONS_SCORE: 0.3592

DSS_SCORE: 0.8182

HELIX: 0.0678

FCONS_SCORE: 1.1155

RIG_SCORE: 0.4967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P790H	ACH-000998	Colon/Colorectal Cancer	CCLE	LPSTPDSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12774	Rho guanine nucleotide exchange factor 5	DEG_SCF_FBW7_1	791:798	LPSTPDSS	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons