DegronMD

Uniprot ID: Q12774

Source protein: Rho guanine nucleotide exchange factor 5

Source gene: ARHGEF5

Class: DEG_SCF_FBW7_1

Location: 509:514

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 94.05

COIL: 0.9702

CONS_SCORE: 0.218

DSS_SCORE: 0.628

HELIX: 0.0087

FCONS_SCORE: 0.8481

RIG_SCORE: 0.6119

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H505R	DO5298	BRCA	ICGC	VTPPRT	DEG_SCF_FBW7_1	0.2222
p.R506G	DO29538	OV	ICGC	VTPPRT	DEG_SCF_FBW7_1	0.25
p.A504P	DO41097	UCEC	ICGC	VTPPRT	DEG_SCF_FBW7_1	0.1944
p.L514M	DO41361	UCEC	ICGC	VTPPRT	DEG_SCF_FBW7_1	0.711
p.G499E	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	VTPPRT	DEG_SCF_FBW7_1	0.0556
p.A504D	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	VTPPRT	DEG_SCF_FBW7_1	0.1944
p.V502L	GCT	soft_tissue	COSMIC	VTPPRT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12774	Rho guanine nucleotide exchange factor 5	DEG_SCF_FBW7_1	509:514	VTPPRT	FBXW7	0.9831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons