DegronMD - Q8IWB1(ITPRIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M196I	TCGA-09-2055	OV	TCGA	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.1389
p.M196I	DO32676	OV	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.1389
p.P216H	TCGA-ER-A19C	SKCM	TCGA	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.1944
p.P216H	DO47353	SKCM	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.1944
p.H209Q	TCGA-V1-A9Z8	PRAD	TCGA	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation altering degron motif	0.647
p.H209Q	DO219393	PRAD	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation altering degron motif	0.647
p.V212M	DO222769	COCA	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.3056
p.P213S	SIDM00215	Colorectal Carcinoma	GDSC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.2778
p.P213S	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.2778
p.P213S	SNU-283	large intestine	COSMIC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.2778
p.N199K	SIDM00705	Non-Cancerous	GDSC	DRPLLCHLF	DEG_APCC_DBOX_1	203:211	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons