DegronMD

Uniprot ID: Q8IWB1

Source protein: Inositol 1,4,5-trisphosphate receptor-interacting protein

Source gene: ITPRIP

Class: DEG_APCC_DBOX_1

Location: 203:211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5081

ASA_SCORE: 49.3111

COIL: 0.4341

CONS_SCORE: 0.6161

DSS_SCORE: 0.0774

HELIX: 0.0186

FCONS_SCORE: 0.9237

RIG_SCORE: 0.9009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M196I	TCGA-09-2055	OV	TCGA	DRPLLCHLF	DEG_APCC_DBOX_1	0.1389
p.M196I	DO32676	OV	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	0.1389
p.P216H	TCGA-ER-A19C	SKCM	TCGA	DRPLLCHLF	DEG_APCC_DBOX_1	0.1944
p.P216H	DO47353	SKCM	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	0.1944
p.H209Q	TCGA-V1-A9Z8	PRAD	TCGA	DRPLLCHLF	DEG_APCC_DBOX_1	0.647
p.H209Q	DO219393	PRAD	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	0.647
p.V212M	DO222769	COCA	ICGC	DRPLLCHLF	DEG_APCC_DBOX_1	0.3056
p.P213S	SIDM00215	Colorectal Carcinoma	GDSC	DRPLLCHLF	DEG_APCC_DBOX_1	0.2778
p.P213S	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	DRPLLCHLF	DEG_APCC_DBOX_1	0.2778
p.P213S	SNU-283	large_intestine	COSMIC	DRPLLCHLF	DEG_APCC_DBOX_1	0.2778
p.N199K	SIDM00705	Non-Cancerous	GDSC	DRPLLCHLF	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWB1	Inositol 1,4,5-trisphosphate receptor-interacting protein	DEG_APCC_DBOX_1	203:211	DRPLLCHLF	APC,CDC20,FZR1	0.5081	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons