DegronMD - Q8IWD4(CCDC117)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P256S	TCGA-AG-3881	READ	TCGA	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S262Y	TCGA-AG-A002	READ	TCGA	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1389
p.R249I	TCGA-AP-A056	UCEC	TCGA	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.8102
p.S254L	SIDM00327	Hodgkin's Lymphoma	GDSC	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.6556
p.S254L	ACH-000754	Lymphoma	CCLE	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.6556
p.S254L	L-428	haematopoietic and lymphoid tissue	COSMIC	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.6556
p.R257Q	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2778
p.R257Q	ACH-000343	Lung Cancer	CCLE	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2778
p.R257Q	NCI-H522	lung	COSMIC	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2778
p.R239Q	NCI-H522	lung	COSMIC	RTELFSE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons